Dogs as Sentinels for Human Infection with Japanese Encephalitis Virus

Because serosurveys of Japanese encephalitis virus (JEV) among wild animals and pigs may not accurately reflect risk for humans in urban/residential areas, we examined seroprevalence among dogs and cats. We found that JEV-infected mosquitoes have spread throughout Japan and that dogs, but not cats, might be good sentinels for monitoring JEV infection in urban/residential areas

A hard ionizing spectrum in z=3-4 Lyα emitters with intense [OIII] emission: Analogs of galaxies in the reionization era?

We present Keck/MOSFIRE spectra of the diagnostic nebular emission lines [O iii]λλ5007,4959, [O ii]λ3727, and Hβ for a sample of 15 redshift z≃3.1\mbox-3.7 Lyα emitters (LAEs) and Lyman break galaxies (LBGs). In conjunction with spectra from other surveys, we confirm earlier indications that LAEs have a much higher [O iii]/[O ii] line ratio than is seen in similar redshift LBGs. By comparing their distributions on a [O iii]/[O ii] versus R23 diagram, we demonstrate that this difference cannot arise solely because of their lower metallicities but most likely is due to a harder ionizing spectrum. Using measures of Hβ and recombination theory, we demonstrate, for a subset of our LAEs, that ξion—the number of Lyman continuum photons per UV luminosity—is indeed 0.2–0.5 dex larger than for typical LBGs at similar redshifts. Using photoionization models, we estimate the effect this would have on both [O iii]/[O ii] and R23 and conclude such a hard spectrum can only partially explain such intense line emission. The additional possibility is that such a large [O iii]/[O ii] ratio is in part due to density rather than ionization bound nebular regions, which would imply a high escape fraction of ionizing photons. We discuss how further observations could confirm this possibility. Clearly LAEs with intense [O iii] emission represent a promising analog of those z > 7 sources with similarly strong lines that are thought to be an important contributor to cosmic reionization

Spontaneous Basal Cell Carcinoma of the Submandibular Gland in a Rat

At necropsy, a white nodule (about 5 × 3 mm in size) was observed in the right submandibular gland of a 10-week-old female GALAS rat. Histopathologically, oval to spindle-shaped and pale basophilic tumor cells proliferated closely, and formed variably sized foci. The nodule partially spread into or invaded the surrounding normal tissue, and necrotic foci were recognized in the tumor. Immunohistochemically, the nuclei of the tumor cells showed a diffusely positive reaction for p63, and the cytoplasm showed a diffusely positive reaction for cytokeratin and negative reaction for αSMA, vimentin, desmin and S-100. Many tumor cells were positive for PCNA. Ultrastructurally, the tumor cells contained many tonofilaments in the cytoplasm and a few desmosomes at the intercellular portion. Based on these findings, the tumor was diagnosed as a basal cell carcinoma originating from the duct in the rat submandibular gland

Etiology of recurrent cystitis in postmenopausal women based on vaginal microbiota and the role of Lactobacillus vaginal suppository

Background: The vaginal microbiota can be altered by uropathogenic bacteria associated with recurrent cystitis (RC), and the vaginal administration of Lactobacillus have suggested certain effects to prevent RC. The relationship between vaginal microbiota and the development of RC has not been elucidated. We aimed to clarify the etiology of RC from vaginal microbiota and importance of vaginal Lactobacillus. Methods: Vaginal samples obtained from 39 postmenopausal women were classified into four groups: healthy controls; uncomplicated cystitis; RC; and prevention (prevented RC by Lactobacillus crispatus-containing vaginal suppositories). Principal coordinate analysis and beta-diversity analysis was used to assess 16S rRNA gene sequencing data from the vaginal microbiome. Results: Cluster analysis divided the vaginal bacterial communities among 129 vaginal samples into three clusters (A, B, and C). Fourteen of 14 (100%) samples from the RC group and 51 of 53 (96%) samples from the prevention group were in clusters B and C, while 29 of 38 (76%) samples from the healthy group and 14 of 24 (58%) samples from the uncomplicated cystitis group were in cluster A. The principal coordinate analysis showed that plots in the uncomplicated cystitis group were similar to the healthy group, indicating a large separation between the RC group and the uncomplicated cystitis group. On beta-diversity analysis, there were significant differences between the healthy group and the uncomplicated cystitis group (p = 0.045), and between the RC group and the uncomplicated cystitis group or the healthy group (p = 0.001, p = 0.001, respectively). There were no significant differences between the RC group and the prevention group (p = 0.446). The top six taxa were as follows: Prevotella, Lactobacillus, Streptococcus, Enterobacteriaceae, Anaerococcus, and Bifidobacterium. Among patients with RC, Lactobacillus was undetectable before administration of suppositories, while the median relative abundance of Lactobacillus was 19% during administration of suppositories (p = 0.0211), reducing the average cystitis episodes per year (6.3 vs. 2.4, p = 0.0015). Conclusion: The vaginal microbiota of postmenopausal women with RC is differed from healthy controls and uncomplicated cystitis in terms of lack of Lactobacillus and relatively dominant of Enterobacteriaceae. Vaginal administration of Lactobacillus-containing suppositories can prevent RC by stabilizing vaginal dysbiosis and causing a loss of pathogenic bacteria virulence

Comparing the minimum income standard in the UK and Japan: methodology and outcome

Minimum Income Standard (MIS) research involves an innovative methodology that combines consensual decisions made through discussion by members of the public, supported by input from experts. MIS addresses questions about income adequacy, and in particular, what is the income that people need in order to reach a minimum socially acceptable standard of living. The first MIS for Britain was published in the UK in 2008, and in 2010 researchers from Japan and the UK began to collaborate on developing a comparable Minimum Income Standard for Japan. This article discusses the differences and similarities between the UK and Japanese MIS. It looks at the challenges of applying the methodology in a very different setting and compares the results of the research in the UK and in Japan. Although there are notable differences in the lists of goods and services that comprise the budgets, there are also some striking similarities. This research suggests that the MIS methodology offers an approach that can be used in different countries to inform discussions on contemporary living standards and societal norms, and to enable international comparisons to be drawn

The Number Density of Old Passively-Evolving Galaxies at z=1 in the Subaru/XMM-Newton Deep Survey Field

We obtained the number counts and the rest-frame B-band luminosity function of the color-selected old passively-evolving galaxies (OPEGs) at z=1 with very high statistical accuracy using a large and homogeneous sample of about 4000 such objects with z' <25 detected in the area of 1.03 deg^2 in the Subaru/XMM-Newton Deep Survey (SXDS) field. Our selection criteria are defined on the i'-z' and R-z' color-magnitude plane so that OPEGs at z=0.9-1.1 with formation redshift z_f=2-10 are properly sampled. The limiting magnitude corresponds to the luminosity of galaxies with M_*+3 at z=0. We made a pilot redshift observations for 99 OPEG candidates with 19 < z' < 22 and found that at least 78% (73/93) of the entire sample, or 95% (73/77) of these whose redshifts were obtained are indeed lie between z=0.87 and 1.12 and the most of their spectra show the continuum break and strong Ca H and K lines, indicating that these objects are indeed dominated by the old stellar populations. We then compare our results with the luminosity functions of the color- or the morphologically-selected early type galaxies at z=0 taking the evolutionary factor into account and found that the number density of old passive galaxies with sim M_* magnitude at z~1 averaged over the SXDS area is 40-60% of the equivalently red galaxies and 60-85% of the morphologically-selected E/S0 galaxies at z=0 depending on their luminosity evolution. It is revealed that more than half, but not all, of the present-day early-type galaxies had already been formed into quiescent passive galaxies at z=1.Comment: 28 pages, accepted for publication in Astrophysical Journal. The full version of the paper including Fig.3 and Fig.4 (large size) in full resolution is put at http://optik2.mtk.nao.ac.jp/~yamada/astronomy/sxdsred.htm

Subaru Deep Survey V. A Census of Lyman Break Galaxies at z=4 and 5 in the Subaru Deep Fields: Photometric Properties

(abridged) We investigate photometric properties of Lyman Break Galaxies (LBGs) at z=3.5-5.2 based on large samples of 2,600 LBGs detected in deep (i'~27) and wide-field (1,200 arcmin^2) images taken in the Subaru Deep Field (SDF) and the Subaru/XMM Deep Field (SXDF). The selection criteria for the LBG samples are examined with 85 spectroscopically identified objects and by Monte Carlo simulations. We find in the luminosity functions of LBGs (i) that the number density of bright galaxies (M_{1700}<-22; corresponding to SFR_{corr}>100 Msolar yr^{-1}) decreases significantly from z=4 to 5 and (ii) that the faint-end slope of the luminosity function may become steeper towards higher redshifts. We estimate dust extinction of z=4 LBGs with M<M^* from UV slopes, and obtain E(B-V)=0.15+/-0.03 as the mean value. The dust extinction remains constant with apparent luminosity, but increases with intrinsic luminosity. We find no evolution in dust extinction between LBGs at z=3 and 4. We investigate the evolution of UV-luminosity density at 1700A, rho, and find that rho does not significantly change from z=3 to z=5, i.e., rho(z=4)/rho(z=3)=1.0+/-0.2 and rho(z=5)/rho(z=3)=0.8+/-0.4, thus the cosmic star-formation rate (SFR) density remains constant. We find that the stellar mass density estimated from the cosmic SFR is consistent with those derived directly from the stellar mass function at z=0-1, but exceeds those at z~3 by a factor of 3. We find that the ratio of the UV-luminosity density of Ly-a emitters (LAEs) to that of LBGs is ~60% at z=5, and thus about a half of the star formation at z=5 probably occurs in LAEs. We obtain a constraint on the escape fraction of UV-ionizing photons produced by LBGs, f_{esc}>~0.13.Comment: 41 pages, 22 figures, ApJ in press. Paper with high resolution figures is available at http://hikari.astron.s.u-tokyo.ac.jp/~ouchi/work/astroph/SDS_V_VI/SDS_V.pdf (PDF

Simulation-based medical education in clinical skills laboratory

Clinical skills laboratories have been established in medical institutions as facilities for simulation-based medical education (SBME). SBME is believed to be superior to the traditional style of medical education from the viewpoint of the active and adult learning theories. SBME can provide a learning cycle of debriefing and feedback for learners as well as evaluation of procedures and competency. SBME offers both learners and patients a safe environment for practice and error. In a full-environment simulation, learners can obtain not only technical skills but also non-technical skills, such as leadership, team work, communication, situation awareness, decision-making, and awareness of personal limitations. SBME is also effective for integration of clinical medicine and basic medicine. In addition, technology-enhanced simulation training is associated with beneficial effects for outcomes of knowledge, skills, behaviors, and patient-related outcomes. To perform SBME, effectively, not only simulators including high-fidelity mannequin-type simulators or virtual-reality simulators but also full-time faculties and instructors as professionals of SBME are essential in a clinical skills laboratory for SBME. Clinical skills laboratory is expected to become an integrated medical education center to achieve continuing professional development, integrated learning of basic and clinical medicine, and citizens’ participation and cooperation in medical education

Testosterone Recovery after Neoadjuvant Gonadotropin-Releasing Hormone Antagonist versus Agonist on Permanent Iodine-125 Seed Brachytherapy in Prostate Cancer Patients: A Propensity Score Analysis

Optimal neoadjuvant hormone therapy (NHT) for reducing prostate cancer (PC) patients’ prostate volume pre-brachytherapy is controversial. We evaluated the differential impact of neoadjuvant gonadotropin-releasing hormone (GnRH) antagonist versus agonist on post-brachytherapy testosterone recovery in 112 patients treated pre-brachytherapy with NHT (GnRH antagonist, n=32; GnRH agonists, n=80) (Jan. 2007-June 2019). We assessed the effects of patient characteristics and a GnRH analogue on testosterone recovery with logistic regression and a propensity score analysis (PSA). There was no significant difference in the rate of testosterone recovery to normal levels (> 300 ng/dL) between the GnRH antagonist and agonists (p=0.07). The GnRH agonists induced a significantly more rapid testosterone recovery rate at 3 months post-brachytherapy versus the GnRH antagonist (p<0.0001); there was no difference in testosterone recovery at 12 months between the GnRH antagonist/agonists (p=0.8). In the multivariate analysis, no actor was associated with testosterone recovery. In the PSA, older age and higher body mass index (BMI) were significantly associated with longer testosterone recovery. Post-brachytherapy testosterone recovery was quicker with the neoadjuvant GnRH agonists than the antagonist, and the testosterone recovery rate was significantly associated with older age and higher BMI. Long-term follow-ups are needed to determine any differential effects of GnRH analogues on the quality of life of brachytherapy-treated PC patients